Elevated plasma concentrations of IL-6 significantly increased the risk of CCA: for every 10 pg/ml increase of plasma IL-6 concentration, there was a 26% (OR = 1.26; 95% CI 1.19 to 1.34, P<0.001) increase in the risk of CCA in a model adjusted for age and sex. Here, IL6 is linked to cholangiocarcinoma.