Recently, a non-synonymous SNP (rs738409), characterized by a C to G substitution encoding an isoleucine to methionine substitution at the amino acid position 148 in the patatin like phospholipase 3 gene (PNPLA3), was found to be associated with hepatic steatosis in a multiethnic cohort of adults [2] as well as in children [3], [4]. The gene discussed is PNPLA3; the disease is Hepatic steatosis.