Single investigated CpG of p16 (OR 10.4, 95%CI 2.0-54.7), BCL2 (OR 33.8, 95%CI 3.6-314.3), CD44 (OR 10.3, 95%CI 2.0-52.3) and TNFRSF10C (OR 11.8, 95%CI 2.2-64.1) were associated with pancreatic cancer. This evidence concerns the gene TNFRSF10C and familial pancreatic carcinoma.