BDKRB1 and neoplasm: This may involve direct activation of the B1R at the tumor vasculature causing i) increased blood flow (hyperemia) through arterial/arteriolar vasodilatation, ii) increase in venular tone (venocontriction) leading in both cases to a rise in capillary hydrostatic pressure and/or iii) increased capillary/venule permeability by retraction (fenestration) of the endothelial cells.