We used high-field MRI to show that the B1R agonist NG29 can induce rapid transvascular delivery and uptake increment (about 1.5-fold higher) of both Magnevist (0.5 kDa) and Gadomer (17 kDa) into intracerebral F98 glioma in syngeneic Fischer rats, as shown by the increase of T1 MRI intensity signals (Figures 3 and 4). The gene discussed is BDKRB1; the disease is central nervous system cancer.