In an initial effort to translate the results from the animal model to humans, we also examined the expression of B1R in well-established human glioblastoma cell lines, clinical glioma specimens of varying grades, and post-mortem normal control human brain biopsies (Figure 2A–D) using the same techniques used to quantify B1R expression profiles in rats. Here, BDKRB1 is linked to central nervous system cancer.