BDKRB1 and central nervous system cancer: In addition, our findings showed that there is concordant high-level expression of (vascular and tumoral) B1R on malignant tumors in the preclinical F98 glioma xenograft model (Figure 1), in various human glioblastoma cell lines and in clinical glioma samples (Figure 2), as shown by our RT-PCR, WB, and IHC results.