Indeed, serum cytokine profile among the patients with established RA in this study revealed that levels of most inflammatory cytokines, including IL-6, TNF, and IL-17, were decreasing with decreasing CRP level over 54-week of infliximab therapy, whereas C2C/CPII level deteriorated over time (unpublished data, Fig. S1). This evidence concerns the gene IL17A and rheumatoid arthritis.