Median IFN-γ responses did not differ significantly in individuals with smear-positive vs. -negative definite TB [114 (IQR: 63-208) vs. 92 (30, 172) SFC•10−6 PBMCs for TSPOT.TB (p = 0.12); 2.3 (0.7–5.5) vs. 1.6 (0.4–4.8) IU⋅ml−1 for QFT-GIT (p = 0.14); 100 (51–158) vs. 99 (18–151) SFC⋅10−6 PBMCs for PPD (p = 0.39)]. The gene discussed is IFNG; the disease is tuberculosis.