Quantitative IFN-γ responses to RD-1 specific antigens or PPD did not change on a per patient basis between 0 vs. 2 months (p-values of 0.51, 0.88 and 0.26 for TSPOT.TB, QFT-GIT and PPD, respectively) or between 0 vs. 6 months (p-values of 0.83, 0.32, and 0.11 for each test) in individuals with definite TB (Figure 3). This evidence concerns the gene IFNG and tuberculosis.