Furthermore, no longitudinal changes in IFN-γ response were detected in individuals who culture converted at 2 months, irrespective of the type of IGRA used (p-values of 0.27, 0.60, and 0.22 respectively for individuals culture-negative at 2 months; p-values of 0.08, 0.24 and 1.00 for TSPOT.TB, QFT-GIT and PPD respectively for individuals still culture-positive at 2 months) (Table 3). This evidence concerns the gene IFNG and tuberculosis.