As the soluble mediators IFNγ and TNF are crucial to control infection of mice deficient for either of these mediators that rapidly succumb to infection [40], [41], we chose to adoptively transfer macrophages from LysM- PPARγKO or LysM- PPARγWT into the peritoneal cavity of IFNγ−/− or TNF−/− mice prior to infection of the mice. The gene discussed is TNF; the disease is infection.