BCL2 and cancer: In order to further detect the role of TrxR1 in IL-24-coupled Bcl-2 S-denitrosylation, we treated these three cancer cells with TrxR1 inhibitor auranofin to detect the alterations of TrxR1 expression, Bcl-2 expression, Bcl-2 S-nitrosylation, and Bcl-2 ubiquitination.