In conclusion, this work is the first report to provide in vitro and in vivo evidences demonstrating that the E2F pathway exerts at direct transcriptional control on RIP140 expression and that this regulation may play an important role in physiological responses to E2F1 on key processes such as proliferation, apoptosis or differentiation which are strongly disturbed in cancer or metabolic diseases. The gene discussed is E2F1; the disease is cancer.