In conclusion, this work is the first report to provide in vitro and in vivo evidences demonstrating that the E2F pathway exerts at direct transcriptional control on RIP140 expression and that this regulation may play an important role in physiological responses to E2F1 on key processes such as proliferation, apoptosis or differentiation which are strongly disturbed in cancer or metabolic diseases. This evidence concerns the gene NRIP1 and cancer.