Silencing of S100P decreases pancreatic cancer cell growth, motility, invasion, and survival in vitro, whereas S100P overexpression increases pancreatic cancer cell aggressiveness and is associated with increased pancreatic tumor growth and metastasis in vivo (Arumugam et al. 2005; Pajonk et al. 2010). Here, S100P is linked to familial pancreatic carcinoma.