Results indicated that AZGP1 expression, as well as serum AFP level, tumor size, tumor multiplicity, tumor differentiation, clinical stage and vascular invasion, was one of the factors that are responsible for efficacy of surgical treatment in HCC patient, by showing that AZGP1 expression was significantly correlated to OS (P = 0.007) and DFS (P = 0.033) of HCC patients. The gene discussed is AZGP1; the disease is hepatocellular carcinoma.