Furthermore, Lockett et al. report that the PARP-1 activity with 762Ala is decreased compared to the PARP-1 762Val, and the PARP-1 Ala762Ala(GCG/GCG) genotype is associated with an increased risk for prostate cancer in Caucasian subjects [16]. The gene discussed is PARP1; the disease is prostate cancer.