NFKB1 and neoplasm: It has also been shown both in vitro and in vivo that dendritic cells (DC, key antigen-presenting cells in the immune system) treated with fever-like heat (41°C) were significantly superior compared to non-heat-treated DC in stimulating T cells and activating NF-κB (a transcription factor that regulates various immunological genes and plays an important role in human tumor suppression) [5], [15].