Second, the purpose of the present article was to show that like a number of other tumors (lung, ovarian, breast, gliomas), meningiomas expressed EGFR isoforms other than the whole one (isoform a), and this may have important implications in the assessment of EGFR expression, particularly by immunohistochemistry, or for the development of new therapies. This evidence concerns the gene EGFR and central nervous system cancer.