In Black individuals, a potential four-order interaction MSH2 (rs3771280) * MSH3 (rs1428030) * PMS1 (rs13404927) *PMS1 (rs5742938) demonstrated strong association with increased risk for malignancy, whereas interaction MSH2 (rs3771280) * PMS1 (rs13404927) * MSH3 (rs26279) significantly decreased the risk for cancer in Mixed Ancestry subjects (Table 5). The gene discussed is MSH2; the disease is cancer.