The multi-locus genotype CTrs3771280−GGrs13404927−AGrs26279 was strongly associated with reduced risk for cancer (P = 0.0028), whereas the genotype TT/AA/GG/GG from interaction MLH1 (rs13320360) *MSH2 (rs10188090) *PMS1 (rs13404927) *PMS1 (rs5742938) was more than 2-fold higher in cancer patients than in healthy individuals (Table 5). The gene discussed is MLH1; the disease is cancer.