HDAC6 is concentrated in Lewy bodies in PD and dementia with LBs, and the Drosophila histone deacetylase 6 (dHDAC6) was shown to play a critical role in the protection of dopaminergic neurons and promoted the formation of α-synuclein inclusions in a Drosophila PD model expressing human α-synuclein. Here, HDAC6 is linked to Parkinson disease.