Moreover, in addition to the genes mapped to the sequentially numbered PARK1-15 loci, other genes, such as MAPT, ATXN2, ATXN3, spatacsin, and POLG1 (Table 2), are known to cause syndromes that can clinically manifest with parkinsonism as one of the symptoms [24]. The gene discussed is SPG11; the disease is Parkinson disease.