Accessed on October 2011 the PDGene database contained 886 updated meta-analyses of the literature, overall suggesting that 18 loci could contribute to sporadic PD risk, including most of those already described (SNCA, LRRK2, MAPT, GBA, HLA-DRB5, BST1, GAK, ACMSD, STK39, MCCC1/LAMP3, SYT11, CCDC62/HIP1R, GWA 8p22, GPNMB) and additional ones (PM20D1, SETD1A, FAM47E and MED13) [52]. This evidence concerns the gene GAK and Parkinson disease.