VEGFA and myocardial infarction: Conversely, activation of SIRT1 by resveratrol induced up-regulation of vascular endothelial growth factor (VEGF) and its tyrosine kinase receptor Flk-1, along with nitric oxide synthase (inducible NOS and endothelial NOS) 3 weeks after myocardial infarction, resulting in increased capillary density in rats [33].