Further conformation in a different cohort of end-stage COPD lungs and in liver cirrhosis tissues showing that SNAI1, KLF9 and KLF10 are higher expressed in ZZ relative to MM AAT subjects, allows us to propose that the increased expression of zinc finger transcription factors is related to AATD. The gene discussed is KLF10; the disease is alpha 1-antitrypsin deficiency.