It has previously been shown that an immediate effect of ADT involves induction of acute hypoxia, including activation and stabilization of the hypoxia-inducible factor 1α (HIF-1α), and subsequent expression of HIF-1α target genes, such as the vascular endothelial growth factor (VEGF) [15-17], a key player involved in tumor neovascularization. Here, HIF1A is linked to neoplasm.