In addition, CD4+CD25highFoxP3+ regulatory T cells (Tregs), which are pivotal in the maintenance of T-cell homeostasis and are critical regulators of immune tolerance [7,8], exhibit quantitative and/or qualitative deficiencies in SLE that may contribute to the development of lupus pathogenesis [9,10]. The gene discussed is CD4; the disease is systemic lupus erythematosus.