Other adipokines such as resistin, visfatin, vaspin, omentin, serum-retinol-binding protein (RBP)-4, chemerin, interleukin (IL)-6, plasminogen activator inhibitor (PAI-1), tumor necrosis factor (TNF), alpha, serum amyloid A, and angiotensinogen may have a role in obesity and T2D. The gene discussed is TNF; the disease is type 2 diabetes mellitus.