The Medical Subject Headings (MeSH) and keywords “childhood cancer,” “pediatrics/child/paediatric,” “neoplasms/malignancy,” “menarche,” “menopause/premature menopause/amenorrhea/female infertility/ovarian failure,” “pregnancy/pregnancy complications/pregnancy outcome,” “fertility preservation,” “GnRH analogues/GnRH agonist,” “ovarian tissue cryopreservation,” “embryo freezing/embryo cryopreservation,” and “oocyte cryopreservation” were used. The gene discussed is GNRH1; the disease is childhood malignant neoplasm.