MTOR and acute myeloid leukemia: Clinical trials evaluating mTOR inhibitors in LAM and AML are currently accruing; it is unlikely given their rarity that PEComa-NOS treatment will be evaluated separately in a randomized fashion, so use of mTOR inhibitors in this setting will likely be in the setting of Phase I trials and/or off-label based on results of the above-mentioned trials in AML and LAM.