In parallel, mice that are heterozygous for Ptch1 demonstrate a phenotype similar to patients with Gorlin syndrome [67]; however, differences in mouse strain or background have a marked effect on susceptibility to RMS, which may explain the overall low frequency of RMS in Gorlin syndrome patients, when compared to BCC and medulloblastoma [68]. Here, PTCH1 is linked to nevoid basal cell carcinoma syndrome.