[14, 15] Of particular interest is the inhibition of IKK and IKKβ as these modulate expression of NF-κB through phosphorylation of IκB leading to IκB degradation and subsequent release and activation of NF-κB.[38, 39] NF-κB has been previously shown to be a prognostic marker and a therapeutic target in CLL [9, 11, 40] and the ability to suppress NF-κB activation in CLL cells may be critical to the success of a treatment. The gene discussed is IKBKB; the disease is B-cell chronic lymphocytic leukemia.