NFKB1 and Sepsis: In addition, studies have shown that neutrophil accumulation after vascular endothelial injury contributes not only to the development but also to the initiation of NIH.46 Moreover, the pre-operative neutrophil NF-κB status has been suggested as a marker of post-operative organ dysfunction and future studies are warranted to assess the role of NF-κB in neutrophil activation and organ dysfunction following surgery.47 The activated neutrophil plays a central role in sepsis (secondary or severe systemic inflammation), which is often present in a patient post vascular intervention.