WEE1 and peripheral neuropathy: Damage to peripheral nerves leads to a rapid influx of Ca++ and Na+, which elicits electrical responses that back-propagate to the cell body in the dorsal root ganglion (DRG) and contribute to the activation of several protein kinase pathways, including protein kinase (PK) A, PKC, and mitogen-activated protein kinases (MAPKs) [5,6].The MAPK family comprises three major members: extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), all of which are implicated in the nociceptor sensitization that is associated with inflammation and peripheral neuropathy [7-9].