Furthermore, several studies investigating the role of DLC1 in breast cancer found that forced expression of DLC-1 in DLC-1 negative breast cancer cell lines resulted in growth inhibition, reduction in colony formation, and abolishment of in vivo tumorigenicity [103,105], whereas downregulation of DLC1 expression enhanced cell motility and chemotactic behavior [106]. Here, DLC1 is linked to breast carcinoma.