The overall OR with its 95% CI showed statistically association between the CASP9 rs105276 polymorphism and the reduced risks of cancers (AA vs GG: OR = 0.75, 95% CI = 0.60–0.92, Pheterogeneity = 0.887; A vs G: OR = 0.85, 95% CI = 0.77–0.95, Pheterogeneity = 0.739 and the recessive model: OR = 0.68, 95% CI = 0.56–0.82, Pheterogeneity = 0.309). The gene discussed is CASP9; the disease is cancer.