NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: Previous studies on Notch receptor function in vascular smooth muscle cells have largely focused on Notch3, due to its relatively specific expression within this cell type and the known association with the human cerebral vascular disease, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) [10], [11], [20].