Results, depicted in Table 3, indicate significant association between hypertension and hif1α (p<0.04), VEGF (p<0.03) and ERCC5 (p<0.02) expression in the maternal plasma. Urine protein, abnormal fetoplacental Doppler and IUGR did not reach significant values among all genes tested. For outcomes that did not meet the ANCOVA assumptions (normal distribution and constant error variance), p-values were determined by the bootstrap (Table 4). This evidence concerns the gene VEGFA and fetal growth restriction.