BRCA1 and breast cancer: Since the c.693G>A substitution at codon 231 affects splicing of BRCA1 exon 11 and has previously been reported in a patient with breast cancer [12], we decided to evaluate the effects of additional synonymous substitutions in BRCA1 exon 11 (c.825C>T codon 275, c.828A>G codon 276 and c.795T>C codon 265; supporting table S1) that had been identified in patients with breast cancer ascertained by the local regional genetics service in whom no other pathogenic mutation had been found.