Since the c.693G>A substitution at codon 231 affects splicing of BRCA1 exon 11 and has previously been reported in a patient with breast cancer [12], we decided to evaluate the effects of additional synonymous substitutions in BRCA1 exon 11 (c.825C>T codon 275, c.828A>G codon 276 and c.795T>C codon 265; supporting table S1) that had been identified in patients with breast cancer ascertained by the local regional genetics service in whom no other pathogenic mutation had been found. The gene discussed is BRCA1; the disease is breast carcinoma.