CXCL12 and stroke disorder: Multivariate testing showed that the initial severity of stroke was independently associated with the level of circulating CD105+/AV− microparticles (OR, 1.103 for 1 point increase in the NIHSS score on admission; 95% CI, 1.032–1.178) after adjusting for other variables, including the risk factor profiles, time after the onset of stroke, and serum levels of SDF-1α (Table 3).