It is exciting that MENA promoter was found to be associated with β-catenin in a recent screen [38], where chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) was used to identify β-catenin binding regions in HCT116 human colon cancer cells, suggesting that MENA is a Wnt/β-catenin pathway target not only in liver and brain, but also in colon cancer contexts. This evidence concerns the gene EGFR and malignant colon neoplasm.