CARMA3 has been reported to promote ovarian cancer cell progression [17], to increase human breast cancer cell growth and invasion [18], induce invasion of oral squamous cell carcinoma (OSCC) [23]; CARMA3 also plays an important role in atherogenesis [24] and NF-kB activation in airway epithelial cells [25]. This evidence concerns the gene CARD10 and oral cavity squamous cell carcinoma.