Individually, low adiponectin, high A-FABP, TNF-α R2 (a surrogate marker of TNF-α), IL-6 or hsCRP at baseline was independently predictive of 5-year diabetes risk in this cohort, after adjustment for nine conventional risk factors, including age, sex, family history of diabetes, smoking, physical inactivity, hypertension, waist circumference, fasting glucose and dyslipidaemia. This evidence concerns the gene TNF and inherited lipid metabolism disorder.