In a German study [26], adiponectin modestly increased the ROC AUC by 0.011 to 0.831 when added to a basic model which included already the inflammatory markers CRP, IL-6, soluble ICAM-1 and soluble E-selectin levels on top of demographic and lifestyle factors, family history of diabetes, blood pressure, lipid levels. This evidence concerns the gene IL6 and diabetes mellitus.