The entire range of preneoplastic and neoplastic lesions – altered (basophilic) hepatic foci, pericentral hepatocyte dysplasia, well differentiated hepatocellular neoplasms, and aggressive hepatocellular carcinomas – was seen in livers from all DEN-treated FGF19-TG:FGFR4-WT animals by 4 months of age (Fig. 1C) as compared to 10 months of age for the non-DEN-treated FGF19-TG:FGFR4-WT mice. This evidence concerns the gene FGF19 and hepatocellular carcinoma.