Four of these SNPs were also significant when analyzing clinical_malaria versus never_malaria group: rs2706384 - IRF1 (OR: 2.023, 95% CI: 1.371–2.987; P = 0.0002), rs2242665 - CTL4 (OR: 0.564, 95% CI: 0.406–0.784; P = 0.0006), rs4986790 - TLR4 (OR: 0.271, 95% CI: 0.116–0.633; P = 0.002) and rs909253 - LTA+252 (OR: 0.366, 95% CI: 0.192–0.699; P = 0.001). This evidence concerns the gene TLR4 and malaria.