S1PR1 and multiple sclerosis: Miron’s study also has found that the synthetic analog of sphingosine (Fingolimod) FTY720, which was approved as a sphingosine-1-phosphate receptor modulator in multiple sclerosis, induced remyelination and astrogliosis and that the action was mediated via the S1P3 and S1P5 receptors, particularly through the S1P5 which is highly expressed on mature oligodendrocytes.