The same regulatory effects of SOX2 on the expression of WNT1, WNT2, NOTCH1 and c-MYC were also observed in the human large cell lung carcinoma cell line H460 with SOX2 silencing (Fig. 3E).This finding indicates a universal regulatory mechanism of SOX2 on the oncogene network of both human lung cell lines. Here, WNT2 is linked to lung large cell carcinoma.