Except for the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 (NDUFAF1), the UPR proteins altered in transgenic flies carrying these mutants [19] are also altered in the human trabecular meshwork tissue, validating the fly system as a good genetic model of glaucoma. The gene discussed is NDUFAF1; the disease is glaucoma.