For example, Ifit2 was not required for mediating the anti-VSV effect of IFN in mouse embryonic fibroblasts (Figure S5), in primary fetal neurons or in Ifit2-ablated neuroblastoma cells (data not shown), results that are not surprising given the strong tissue-specificity of Ifit2 action observed in vivo (Figure 7). This evidence concerns the gene IFNA1 and neuroblastoma.