In contrast, in acute infection by viruses that cause severe pathogenesis and death within a few days after infection, protection is primarily provided by the intrinsic antiviral actions of IFN-induced proteins encoded by the hundreds of IFN-stimulated genes (ISGs) [10]–[12], several of which often contribute to the overall effect of IFN against a given virus. The gene discussed is IFNA1; the disease is infection.