In addition, a significant negative correlation between serum C4a and ALT levels was observed in the population as a whole (Fig. 3, r=−0.35, P=0.03) and in PNALT patients (Table IV; ALT ≤30 IU/l; Fig. 3), but not in CHC-2 patients (ALT >30 IU/l; Fig. 3). This evidence concerns the gene GPT and cryohydrocytosis.