We also tested three aromatase inhibitors (anastrozole, letrozole, and exemestane), and two estrogen-receptor antagonists/downregulators (4-hydroxytamoxifen and fulvestrant) and again no effect was shown in the chondrosarcoma cell lines and cultures under the different conditions described in Table 4 (Figure 2Band data not shown). The gene discussed is ESR1; the disease is chondrosarcoma.