In fact, a recent study performed in 129SvJ mice found that chronic stress combined with a high fat/high sugar diet led to abdominal obesity by releasing NPY directly into the adipose tissue.127 Moreover, the same study found that, in vitro, sympathetic neurons stressed with dexamethasone shifted toward expressing more NPY, which in turn stimulated endothelial cells, macrophage infiltration, and preadipocyte proliferation and lipid filling, by activation of Y2 receptors (NPY2R). Here, NPY is linked to Abdominal obesity.