NPY and obesity due to melanocortin 4 receptor deficiency: These new findings may extend the results of Dallman's studies on the role of so-called comfort foods in the response to chronic stress, suggesting that by activating the sympathetic drive, leading in turn to peripheral NPY overexpression and action, the ingestion of high fat-high carbohydrate foods might be responsible for stress-related obesity and metabolic comorbidities.