As occurs in women with the polycystic ovary syndrome, there are theoretical bases to suggest that an insulin-mediated overstimulation of ovarian steroidogenesis may occur in females with abdominal obesity, as insulin acts as a true gonadotropic hormone, synergizing LH activity.89 However, there are no consistent in vitro or in vivo data supporting a clear responsibility of insulin—or other factors mimicking insulin action, such as the insulin growth factor-1 (IGF-1)—in women with abdominal obesity. The gene discussed is INS; the disease is polycystic ovary syndrome.