IL1B and adult-onset Still disease: However, a growing number of experimental evidences supports the hypothesis that a disregulation of inflammasome complex and a related overproduction of the proinflammatory cytokine interleukin 1β (IL-1β) is a pivotal event in the pathogenesis of this disorder, in analogy with other autoinflammatory diseases that share with AOSD clinical and biological characteristics [3].