Increase in mRNA and protein levels of LPL might increase the activity of LPL in the adipose tissue and plasma, promote the clearance of VLDL and postprandial plasma lipid, reduce plasma triglycerides, increase HDL-C levels, and therefore prevent hypercholesterolemia induced by high fat diet and development of atherosclerosis [21, 22]. Here, LPL is linked to familial hypercholesterolemia.