When specific immune response fails to control viral replication, the infected liver cells secrete IFN-gamma-induced chemokines such as CXC chemokine ligand CXCL9, CXCL10, and CXCL11, which result in the migration of nonspecific mononuclear cells into the liver [39], which are unable to control infection but result in sustained liver damage [40]. This evidence concerns the gene IFNG and infection.