TOR1A and early-onset generalized limb-onset dystonia: In one report, pathological abnormalities were described in brains of DYT1 patients, included ubiquitin and torsinA-positive inclusions in neurons in the brainstem, ubiquitin-positive inclusions in pigmented neurons in the substantia nigra and locus coeruleus, as well as elevated levels of tau, a protein associated with microtubules (MTs) [20].