TFAM and Alzheimer disease: Increased oxidative stress in DS and AD correlates with a decrease in several mitochondrial components including complex IV nuclear encoded subunit IV, mtDNA encoded subunit I [32], complex I nuclear encoded 24 and 75 kDa subunits [33], complex V nuclear encoded β subunit and complex III nuclear encoded core protein I [23], and mitochondrial ATPase6 and mitochondrial transcription factor A (Tfam) [34].